SPMs 👩🔬
Specialised Proresolving Lipid Mediators
Specialized pro-resolving mediators (SPMs) are endogenous small
molecules produced mainly from dietary omega-3 polyunsaturated fatty
acids by both structural cells and cells of the active and innate immune
systems. Specialized pro-resolving mediators have been shown to both
limit acute inflammation and promote resolution and return to
homeostasis following infection or injury. There is growing evidence
that chronic immune disorders are characterized by deficiencies in
resolution and SPMs have significant potential as novel therapeutics to
prevent and treat chronic inflammation and immune system disorders. This
review focuses on important breakthroughs in understanding how SPMs are
produced by, and act on, cells of the adaptive immune system,
specifically macrophages, B cells and T cells. We also highlight recent
evidence demonstrating the potential of SPMs as novel therapeutic agents
in topics including immunization, autoimmune disease and
transplantation.
Learn more about SPMs