As you ride, you will be using nearly all the muscles in your body. The two most obvious muscles are your heart and your thighs. Other muscles include calves, core, shoulders, forearms, neck, and back (not to mention hamstrings). Riding a bike is an excellent way to strengthen your heart. The fact of the matter is that heart disease is the number one killer of women; In 2015, The American Heart Association concluded that “every minute in the United States, someone’s wife, mother, daughter or sister dies from heart disease, stroke or another form of cardiovascular disease (CVD).